MIT · Guggenheim Fellow · Wilhelm Exner Medal
Prof. Shuguang Zhang
Shuguang Zhang invented whole categories of science and industries. While at MIT, he discovered that short peptides, tiny fragments of protein, can spontaneously organize themselves into stable, ordered structures. That observation became the foundation of molecular self-assembly with designer peptides, a discipline now practiced in laboratories on every continent and taught as a cornerstone of modern biomaterials science.
What sets his career apart is how relentlessly that one idea has been pushed into the real world. His designer peptide scaffolds give nerve and stem cells a place to grow, his hydrogels repair cartilage and tissue, one of his materials halts bleeding in seconds, and his QTY code rewrites notoriously difficult membrane proteins into water-soluble forms that drug discovery can finally work with. Each of Shuguang's advances has spun off patents, products, and companies. Basic science translated, again and again, into tools other people can use.
The recognition has matched the reach. He is a John Simon Guggenheim Fellow and a recipient of the Wilhelm Exner Medal, an Austrian honor for scientists whose work transforms industry. The medal has gone to the builders of modern communications and transportation: Guglielmo Marconi, the leaders of Volkswagen, Porsche and Bosch. Add to that election to academies of science across Europe, Asia and the Americas, dozens of patents, and a research record spanning hundreds of journal papers. The full record is below, beginning with the headlines his research has made, followed by his positions, honors, patents, and publications.
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Education
- 1982-1988 Ph.D. Biochemistry & Molecular Biology
- Department of Biological Sciences
- University of California at Santa Barbara, USA
- 1977-1980 B.S. Biochemistry
- Department of Biology
- Sichuan University, China
Positions Held
- 2019-2025 Head, Laboratory of Molecular Architecture, The Media Lab, MIT
- 2012-2019 Head, Laboratory of Molecular Architecture, Center for Bits and Atoms, MIT
- 1998-2012 Associate Director, Center for Biomedical Engineering, MIT
- 1997-2012 Principal Research Scientist, Center for Biomedical Engineering, MIT
- 1995-1997 Research Scientist, Center for Biomedical Engineering, MIT
- 1992-1995 Research Scientist, Department of Biology, MIT
- 1988-1991 American Cancer Society postdoctoral fellow, Department of Biology, MIT
Visiting Positions
- 2005-2006 Sichuan University, Chengdu, China
- 2006-2007 University of Cambridge, Cambridge, UK (Guggenheim Fellowship)
- Department of Biochemistry,
- Department of Materials Science
- 2009-2012 Institute of Bioengineering and Nanotechnology, A*Star, Singapore
- 2012-2016 Nanyang Technological University, Singapore
Honors and Fellowships
- 2025 Foreign member, The Royal Society of Arts and Sciences in Göteborg, Sweden
- 2025 Carleton Gajdusek Medal Lecture, Geneva, Switzerland
- 2024 Eva and George Klein Medal Lecture, Karolinska Institute, Sweden
- 2021- Elected to the European Academy of Science and Arts
- 2021- The Erwin Schrödinger Colloquium, Austrian Academy of Science,
- 2021 Honorary member, the Erwin Schrödinger Society for Nanoscience, Austria
- 2021 Science and Innovation Award, Chinese Association for Science and Technology (CAST-USA)
- 2020 Emil Thomas Kaiser Award, The Protein Society
- 2014 Honorary Professor, Shanghai Jiaotong University, China (No compensation)
- 2013- Elected to National Academy of Inventors
- 2011- Elected to American Institute of Medical and Biological Engineering
- 2010- Elected to Austria Academy of Sciences
- 2010 Honorary Professor, China University of Petroleum (No compensation)
- 2006 Wilhelm Exner Medal, Austria
- 2006 Fellow, John Simon Guggenheim Foundation
- 2004 R& D 100 Award R&D Magazine
- 2004 Top 100 Science Stories (Discover Magazine)
- 2004 Fellow, Japan Association for the Advancement of Medical Equipment
- 2004 Honorary Professor, Sichuan University, China (No compensation)
- 2003 Fellow, Japan Society for Promotion of Science (JSPS Fellow)
- 2001 Finalist, Innovation Award (sponsored by Discover Magazine & Walt Disney)
- 2000 “Who is Who in Science & Engineering in America”
- 1997-2000 Investigator, Whitaker Foundation Biomedical Engineering
- 1994 Elected to New York Academy of Sciences
- 1993 Elected to Sigma Xi Scientific Research Society of North America
- 1993 A discovery selected as one of the 15 research achievements of MIT over last 25 years.
- 1988 American Cancer Society Postdoctoral Fellow
- 1986 University of California Regents Fellowship, UC Santa Barbara
- 1983 Graduate Mentor Fellowship, University of California at Santa Barbara
Research Experience
- Present:
- Molecular design, especially protein and peptide design.
- Designs of water-soluble G protein-coupled receptors and other transmembrane proteins.
- Design of versatile, ultra-sensitive sensing device using biological receptors.
- Interfacing biological system with non-biological system to transduce and amplify information.
- Acknowledged as discoverer/founder of the field of self-assembling peptides.
Teaching Experience
| Semester | Subject Number | Title | Role |
|---|---|---|---|
| FT 2000 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2001 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2002 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2003 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2004 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2005 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2007 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2008 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| FT 2009 | 20.342/442 | Molecular structure of biological materials: structure, function and self-assembly | Lecturer |
| ST 2020 | MAS.S66 | Molecular Architecture and Design | Lecturer |
| ST 2021 | MAS.S65 | Molecular Architecture and Design | Lecturer |
| ST 2022 | MAS.S60 | Molecular Architecture and Design | Lecturer |
| ST 2019 | MAS.S66 | How to Grow (Almost) Anything, | Guest lecturer |
| ST 2020 | MAS.S61 | How to Grow (Almost) Anything, | Guest lecturer |
| ST 2021 | MAS.S63 | How to Grow (Almost) Anything, | Guest lecturer |
| ST 2022 | MAS.S63 | How to Grow (Almost) Anything, | Guest lecturer |
| ST 2023 | MAS.S65 | How to Grow (Almost) Anything, | Guest lecturer |
| ST 2024 | MAS.S65 | How to Grow (Almost) Anything, | Guest lecturer |
| ST 2025 | MAS.S65 | How to Grow (Almost) Anything, | Guest lecturer |
| FT 1994-2023 | 7.A12 | Molecular structure of hereditary materials: Nucleic Acids | Class Leader |
| FT 1997-2002 | Biology Structure & Function Seminar Series | Organizer | |
| FT 2002-2006 | The Christmas Lecture: History of Biology | Organizer |
- MIT Freshman Advisor, 1994-2005, 2007-2009, 2013-2023
- Graduate Ph.D. thesis committee with students for MIT Media Lab, Departments of Biology,
- Biological Engineering, Chemical Engineering, Electric Engineering & Computer Science, Mechanical
- Engineering, Materials Science & Engineering; Ph.D. Thesis committee member for Tufts University;
- Karolinska Institute, Sweden; Swiss Institute of Technology-Lausanne (EPFL), Switzerland.
- Biochemistry laboratory, University of California at Santa Barbara
- Genetics recitation, University of California at Santa Barbara
- Trained numerous undergraduate students at MIT and University of California at Santa Barbara
Professional Associations
| Organization | Date |
|---|---|
| Member, Sigma Xi Scientific Research Society of North America | 1993- |
| Member, New York Academy of Sciences | 1994- |
| Member, American Society of Biochemistry & Molecular Biology | 1994- |
| Member, HUGO Americas (Human Genome Organization) | 1995- |
| Member, Protein Society | 1995-2005, 2020- |
| Elected to Austria Academy of Sciences 2010- | |
| Elected to American Institute of Medical and Biological Engineering 2011 - | |
| Elected to National Academy of Inventors | 2013- |
| Honorary member, the Erwin Schrödinger Society in Nanoscience, Austria | 2021- |
| Elected to the European Academy of Science and Arts | 2021- |
Meetings Organized
- A Symposium to Honor Alexander Rich: Alex in Wonderland. MIT Media Lab, June 1994
- International Conference on Complex Systems Nashua NH, September 1997
- Self-organization in Materials Science MIT Biology, March 1998
- 1st Self-assembling Peptide Systems in Biology, Engineering &
- Medicine
- Crete, Greece, July 1999
- 2nd Self-assembling Peptides & Proteins in Biology, Engineering
- & Medicine
- Crete, Greece July 2001
- American Chemical Society, Section of Biotechnology Boston, July 2002
- 3rdSelf-assembling Peptides & Protein in Biology, Engineering
- & Medicine
- Crete, Greece, August 2003
- 4th Self-assembling Peptides & Proteins in Biology, Engineering
- & Medicine
- Crete, Greece, June 2005
- VI European Protein Society Symposium Barcelona, Spain, May 2005
- Nanobiomedical Technology & Structural Biology Chengdu, China, June 2006
- VII European Protein Society Symposium Stockholm Sweden May 2007
- 3rd Molecular Frontiers Symposium Stockholm, Sweden May 2008
- Mykonos Workshop on Frontiers of Membrane Biology Mykonos, Greece May 2009
- A symposium to honor Alexander Rich: Alex in Wonderland II MIT Media Lab, June 2014
- 1st Peptides & Proteins: Structure, Function & Biotechnology Le Mans, France, July 2013
- 2nd Peptides & Proteins: Structure, Function & Biotechnology Geneva, Switzerland, July 2016
- 3rd Peptides & Proteins: Structure, Function & Biotechnology Geneva, Switzerland, July 2018
- Molecular Frontiers Symposium at MIT Media Lab, November 2018
- 4th Peptides & Proteins: Structure, Function & Biotechnology Geneva, Switzerland, July 2023
- Molecular Frontiers Symposium
- Molecular Frontiers Symposium
- Hong Kong November 2024
- New New York University, Nov. 2025
Scientific Services
- Journal editorial
- Public Library of Science ONE (An open access journal) Academic Editor, 2006-2016
- QRB Discovery, Associate Editor, Cambridge University Press, 2020-
- Book series: Series in Structural biology, Associate Editor, 2012-
- Molecular Frontiers Journal, Associate Editor 2020-
- Declined for all other journal editorial boards
- Journal Referees for:
- Nature
- Nature Biotechnology
- Nature Chemical Biology
- Nature Chemistry
- Nature Communications
- Nature Materials
- Nature Nanotechnology
- Nature Structural Biology
- Science
- Science Advances
- Proceedings of National Academy of Sciences, USA
- PLoS ONE
- Protein Science
- Journal of Molecular Biology
- Journal of American Chemical Society
- Langmuir
- Biomembranes
- Protein Engineering Design & Selection
- Nano Letters
- Nano Today
- Biochemistry
- Biotechnology Advances
- Biomacromolecules
- Macromolecules
- Materials Science & Engineering
- ChemCommincation
- Quarterly Review of Biophysics, Cambridge University Press
- QRB Discovery, Cambridge University Press
- Thin Solid Films
- Advanced Materials
- Supramolecular Chemistry
- Several Journals of the American Chemical Society
- Grant reviews for:
- US National Science Foundation (NSF)
- US National Institute of Health (NIH)
- US Department of Energy (DoE)
- US Department of Defense (DoD)
- American Chemical Society (ACS)
- Alzheimer’s Disease Foundation, USA
- The Wellcome Trust, London, UK
- EPSRC, UK
- European Science Foundation
- Israel Science Foundation, Jerusalem, Israel
- The Royal Society of New Zealand
- Austria, Canada, China, Denmark, Ireland, Czech Republic and Singapore.
Patents
- Zhang; Shuguang, Lockshin; Curtis, Rich; Alexander, Holmes & Todd. Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor. US 5,670,483, September 23, 1997. (Licensed Hercules Corp 1995, then transferred to 3DMatrix 2002).
- Zhang; Shuguang, Lockshin; Curtis, Rich; Alexander, Holmes & Todd. Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor. US Patent 6,548,630. April 15, 2003. (Licensed to 3DMatrix 2002).
- Holmes; Todd, Zhang; Shuguang, Rich; Alexander, DiPersio; C. Michael & Lockshin; Curtis, Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor. US Patent 6,800,481. October 5, 2004. (Licensed to 3DMatrix 2002).
- Holmes; Todd, Zhang; Shuguang, Rich; Alexander, DiPersio; C. Michael & Lockshin; Curtis, Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor. US Patent 7,098,028. August 29, 2006. (Licensed to 3DMatrix 2002).
- Zhang; Shuguang & Schwartz; John J. Modular peptide mediated intracellular delivery system and uses therefor. US Patent 6,844,324, January 18, 2005.
- Zhang; Shuguang, Rich; Alexander, Yan; Lin & Whitesides; George. Self-assembling peptide surfaces for cell patterning and interactions. US Patent 6,368,877. April 9, 2002. (Licensed to Surfacelogix 2002).
- Genove, E., Zhang S., Semino, C. Self-assembling peptides incorporating modifications and methods of use thereof. MIT Case No. 10154, Publication No. US2015/0183828A1, US8,901,084 (Licensed to 3-DMatrix, 2005). • European Patent Office EP1636250B1 issued January 6, 2016. • Switzerland Patent 1636250 issued January 6, 2016. • Germany Patent 1636250 issued January 6, 2016. • Denmark Patent 1636250 issued January 6, 2016. • Finland Patent 1636250 issued January 6, 2016. • France Patent 1636250 issued January 6, 2016. • United Kingdom Patent 1636250 issued January 6, 2016. • Ireland Patent 1636250 issued January 6, 2016. • Japan Patent 1636250 issued January 6, 2016.
- Jacobson; Joseph M., Schwartz; John J., Hamad; Kimberly & Zhang; Shuguang. Direct, externally imposed control of polypeptides. US Patent 6,953,656. October 11, 2005. (Licensed to EugeniOS 2002).
- Jacobson; Joseph M., Schwartz; John J., Hamad; Kimberly & Zhang; Shuguang. Direct, externally imposed control of nucleic acids. US Patent 6,953,659. October 11, 2005. (Licensed to EugeniOS 2002).
- Zhang; Shuguang & Vauthey; Sylvain. Surfactant peptide nanostructures, and uses thereof. US Patent 7,179,784. February 20, 2007. (Licensed to 3DMatrix 2010).
- Zhang; Shuguang & Vauthey; Sylvain. Surfactant peptide nanostructures, and uses thereof. US Patent 7,671,258. March 2, 2010. (Licensed to 3DMatrix 2010).
- Kisiday; John, Grodzinsky; Alan & Zhang; Shuguang. Macroscopic scaffold containing amphiphilic peptides encapsulating cells. US Patent 7,449,180. November 11, 2008. (Licensed to 3DMatrix 2005).
- Ellis-Behnke; Rutledge, Schneider; Gerald & Zhang; Shuguang. Self-assembling peptides for regeneration and repair of neural tissue. US Patent 7,846,891. December 7, 2010.
- Ellis-Behnke; Rutledge, Zhang; Shuguang, Schneider; Gerald, So; Kwok-Fai, Tay; David, Liang; Yu-Xiang. Compositions and methods for promoting hemostasis and other physiological activities. US Patent 9,327,010. May 3, 2016. (Licensed to 3DMatrix 2006).
- Ellis-Behnke; Rutledge, Zhang; Shuguang, Schneider; Gerald, So; Kwok-Fai, Tay; David, Liang; Yu-Xiang. Compositions and methods for promoting hemostasis and other physiological activities. US Patent 9,364,513. June 14, 2016. (Licensed to 3DMatrix 2006).
- Ellis-Behnke; Rutledge, Zhang; Shuguang, Schneider; Gerald, So; Kwok-Fai, Tay; David, Liang; Yu-Xiang. Compositions and methods for promoting hemostasis and other physiological activities. European Patent EP 1 879 606 B1. 12.06.2013 Bulletin 2013/24. (Licensed to 3DMatrix 2006).
- Genove; Elsa, Zhang; Shuguang & Semino; Carlos. Self-assembling peptides incorporating modifications and methods of use thereof. US Patent 7,713,923. May 11, 2010. (Licensed to 3DMatrix 2006).
- Horii; Akihiro, Zhang; Shuguang, Wang; Xiumei & Gelain; Fabrizio. Modified self-assembling peptides. US Patent 8,022,178. September 20, 2011. (Licensed to Olympus 2007). • Japan Patent JP5,496,671B2 issued May 21, 2014 • Japan Patent Applications JP2013229859A, JP2015158226A, and JP2017129570A. • Spain ES 2,709 125T3 Granted
- Kumada; Yoshiyuki & Zhang; Shuguang. Self-assembling peptides incorporating modifications and methods of use thereof. US Patent 8,741,833. June 3, 2014. (Licensed to Olympus 2010, transferred to 3DMatrix, 2014).
- Kumada; Yoshiyuki & Zhang; Shuguang. Self-assembling peptides incorporating modifications and methods of use thereof. US Patent 9,481,713. November 1, 2016. (Licensed to Olympus 2010, transferred to 3DMatrix, 2014 ).
- Koutsopoulos; Sotirios & Zhang; Shuguang. Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies. US Patent 9,700,521. July 11, 2017. • Japan Patent JP6134050B2 issued May 24, 2017 • European Patent Office EP2968135A4 published October 26, 2016. • WIPO Patent Application WO2014152751A1 filed September 25, 2014. • China Patent Application CN 201480014835 filed March 14, 2014; CN105228592A published January 6, 2016.
- Mershin; Andreas, Cook; Brian, Kaiser; Liselotte, Bikker; Johanna F., Miura; Yoshikatsu, Niwa; Daisuke, Ohnishi; Dai, Tazuke; Atsushi & Zhang; Shuguang. Multiplexed olfactory receptor-based microsurface plasmon polariton detector. US Patent 8,748,111. June 10, 2014.
- Mershin; Andreas, Wassie; Asmamaw, Maguire; Yael, Kong; David, Zhang; Shuguang, Moran; Patrick, & Corin; Karolina. Methods and apparatus for artificial olfaction. US Patent 9,140,677. September 22, 2015.
- Mershin; Andreas, Wassie; Asmamaw, Maguire; Yael, Kong; David, Zhang; Shuguang, Moran; Patrick, & Corin; Karolina. Methods and apparatus for artificial olfaction. US Patent 9,377,447. June 28, 2016.
- Zhang; Shuguang, Mershin; Andreas, Kaiser; Liselotte, Cook; Brian, Graveland-Bikker; Johanna F., Prakash; Manu, Kong; David, Maguire; Yael. Bio-sensing nanodevice. US Patent 9,714,941. July 25, 2017.
- Mershin; Andreas, Cook; Brian & Zhang; Shuguang. Bio-sensitized solar cells (BSSC). US Patent 8,796,544. August 5, 2014.
- Zhang; Shuguang, Rich; Alexander, Corin; Karolina, & Tegler; Lotta T. Water soluble membrane proteins and methods for the preparation and use thereof. US Patent 8,637,452. January 28, 2014. (Licensed to OH2LAboratories 2014).
- Zhang; Shuguang, Rich; Alexander, Corin; Karolina, & Tegler; Lotta T. Water soluble membrane proteins and methods for the preparation and use thereof. US Patent 9,309,302. April 12, 2016. (Licensed to OH2LAboratories 2014).
- Zhang; Shuguang, Rich; Alexander, Corin; Karolina, & Tegler; Lotta T. Water soluble membrane proteins and methods for the preparation and use thereof. US Patent 10,035,837. July 31, 2018. (Licensed to OH2LAboratories 2014).
- Zhang; Shuguang, Jin; David, Qing; Rui and Sleytr, Uwe. QTY-Fc fusion receptor proteins. US11,401,320 B2, August 2, 2022.
- Zhang; Shuguang, Qing; Rui, Briewiester; Andreas, and Sleytr, Uwe. S-layer protein 2D lattice coupled detergent-free gpcr bioelectronic interfaces, devices, and methods for the use thereof. WIPO (PCT) WO2019046699A1, 7 March, 2019. Pending patent applications
- Zhang, S., Koutsopoulos, S. & Nagai, Y. Particles and methods for delivering a guest molecule. MIT case 13351. US4041.3008 (filed April 2010)
- Koutsopoulos, S. & Zhang, S. (2012) Sustained delivery of molecules using peptide surfactants and uses thereof. (MIT Case No. 15472). • European Patent Office 2013797704 published April 8, 2015 • Japan Patent Application JP2015515229A filed May 31, 2013 • JP2015519374A published July 9, 2015 • JP2017192847A filed October 2, 2017, published May 4, 2018 • JP2018052935A filed April 5, 2018 • WIPO Patent Application WO2013181511A1 published December 5, 2013.
- Hsu, B., Hammond, P. & Zhang, S. (2015) Hemostatic films based on self-assembling peptides. MIT Case No. 16905. (Filed in 2015).
- Zhang, S., & Tao, F. (2015) Water-soluble membrane proteins and methods for the preparation and uses thereof. MIT Case No. 16938X, US Patent US 2017/03446699 A1, filed March 27, 2015, published November 30, 2017. (Licensed to OH2Laboratories, 2015) • WIPO Patent Application WO2015149085A2 filed March 27, 2015. WIPO Patent Application WO2015148820A1 filed October 1, 2015. • Austrialia 2019 232778 A1 Pub No.: 2019 232778; October 3, 2019 Div of 2015 237137. • Canada Patent Application CA2978076A1 filed October 1, 2015. • EPO Patent Application EP312267A2 filed May 27, 2015. 7, Pub Date Feb 1, 2017 • Japan Patent Application JP 2017 520862A5 Pub Date May, 17, 2018 • Singapore 11 2016 07980UA
- Ellis-Behnke, R., Liang, Y-X., Schneider, G. E., So, K-F., Tay, D. K.C. and Zhang, S. (2016) Compositions and methods for promoting hemostasis and other physiological activities; US15/091,435 Filed: 4/5/2016; Publication No. 2016-0296660A1 Publication Date: 10/13/2016.
- Zhang, S., Qing, R., Sleytr, U.B., & Breitwieser, A. (2018) S-Layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof. US16/118,989 Filed: 8/31/2018. Publication No. 2019-0353654A1, 11/21/2019, MIT Case No. 19759X (June 26, 2017).
- Rui Qing, David Jin & Shuguang Zhang (2020) QTY Code designed water-soluble interferon and interleukin receptor variants and their uses thereof. M.I.T. Case No. 22049J (Filed March 2020).
- Rui Qing, David Jin & Shuguang Zhang (2020) QTY code designed water-soluble CCR9 and CXCR2 receptor variants and their uses thereof. M.I.T. Case No 22272J (Filed March 2020).
- Sleytr, U.B., David Jin, Rui Qing, & Shuguang Zhang (2020) QTY Code designed water-soluble cytokine receptor-Fc fusion variants for extracorporeal sorbent, blood purification and diagnostics and uses thereof. M.I.T. Case No. 22424J. (Filed June 2020).
- Zhang, S. and Jin, David. Designed water-soluble transmembrane glucose transporters. M.I.T. Case No. 24283. (Filed April 2022). Founded Biotech Startups • 3DMatrix, Ltd, 2002 in Cambridge, MA. Moved to Tokyo, Japan in 2007, IPO in 2011. Develop my discovery of self-assembling peptides nanofiber hydrogel for i) accelerated wound healing, ii) sustained molecular delivery; annual revenue over 20 million Euros worldwide. Scientific papers for founding the company Zhang S, et al (1993) Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc. Natl. Acad. Sci. USA 90, 3334-3338. Zhang S, et al (1995) Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials 16, 1385-1393. Ellis-Behnke R, et al (2006) Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc. Natl. Acad. Sci. 103, 5054- 5059. Ellis-Behnke R, et al. (2007) Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine. Nanotechnology, Biology & Medicine 2, 207-215. • OH2Laboratories, LLC 2017, Cambridge, MA. Using the QTY code to design water-soluble GPCRs to generate therapeutic monoclonal antibodies. (Raised ~$7M). Scientific papers for founding the company Zhang S, et al (2018) QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities. Proc. Natl. Acad. Sci. USA 115 (37) E8652-E8659. PMID: 30154163 Qing R, et al (2019) QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand-binding activities. Proc. Natl. Acad. Sci. USA 116 (51) 25668-25676. PMID: 31776256 Hao SL, et al (2020) QTY code-designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands. QRB Discovery 1, e4, PMID: 34192260 Zhang, S. & Egli, M. (2022) Hiding in plain sight: three chemically distinct α-helix types. Quarterly Review of Biophysics (QRB) 55, e7. PMID: 35722863 • 511 Therapeutics, Inc. 2022, Cambridge, MA. Using the QTY code to design water-soluble solute carrier transporters (SLCxxx) to generate therapeutic monoclonal antibodies. (Raised ~$0.55M). Scientific papers for founding the company Zhang S, et al (2018) QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities. Proc. Natl. Acad. Sci. USA 115 (37) E8652-E8659. PMID: 30154163 Qing R, et al (2019) QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand-binding activities. Proc. Natl. Acad. Sci. USA 116 (51) 25668-25676. PMID: 31776256 Hao SL, et al (2020) QTY code-designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands. QRB Discovery 1, e4, PMID: 34192260 Zhang, S. & Egli, M. (2022) Hiding in plain sight: three chemically distinct α-helix types. Quarterly Review of Biophysics (QRB) 55, e7. PMID: 35722863 • RESENSA. To be founded during 2026 in Hong Kong. The technology was through my invention to develop ultra-sensitive molecular detection devices combining water-soluble GPCRs analogs including olfactory receptors, 2D crystal lattice and conducting graphene surface for early disease diagnosis. Scientific papers for founding the company Qing R, et al (2023) Scalable biomimetic sensing system with membrane receptor dual- monolayer probe and graphene transistor arrays. Sci Adv. 2023 Jul 21;9(29):eadf1402. PMID: 37478177. Zhang, S. & Egli, M. (2022) Hiding in plain sight: three chemically distinct α-helix types. Quarterly Review of Biophysics (QRB) 55, e7. PMID: 35722863 • Molecular Trapy. To be founded during 2026 in Shanghai. The technology was through my invention to develop water-soluble membrane proteins including GPCRs and other receptors in combination with Fc of IgG as biologics to treat cancer metastasis and other diseases. Scientific papers for founding the company Sun CF, et al (2025) Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4QTY-Fc as a molecular trap. Cell Chemical Biology 32, 1058-1074. PMID: 40845831 Zhang, S. & Egli, M. (2022) Hiding in plain sight: three chemically distinct α-helix types. Quarterly Review of Biophysics (QRB) 55, e7. PMID: 35722863
Scientific Advisory & Founded Startups
- • Acorda Therapeutics, New York, Scientific Advisor 1995-2001
- • Mitsubishi Chemical Corporation Research Center, Yokohama, Japan 1998-2003
- • Menicon Co. Ltd., Nagoya, Japan, Scientific Advisor 2005-2007
- • 3D Matrix, Ltd. Tokyo, Japan, Scientific Advisor 2005-
- • OH2Laboratories, Cambridge, MA, USA 2017-
- • MIXBio (Shanghai) Co. Ltd 2022-
- • RealNose, Arlington, MA, USA 2023-
- • UltraDx Biotechnology (Shanghai) Co. Ltd 2024-
- • Nuacres GmbH, Berlin, Germany 2025-
- • AAira, Inc, Berkeley, California 2025-
Books
- Self-assembling Peptide Systems in Biology, Engineering and Medicine. Kluwer Academic Publishers, Aggeli, A., Boden, N. & Zhang, S. (Editors) (2001) Dordrent, The Netherlands.
- The Struggles and Dreams of Robert Langer (Structural Biology) 1st Edition, Robert Langer (Author), Zhang, S. (Editor), (2016) World Scientific Publishing.
- Excitement of Discovery: A tribute to Alexander Rich, Zhang, S. (Editor) (2018) World Scientific Publishing.
Journal Papers
- Zhang, S., Lockshin, C., Herbert, A., Winter, E. & Rich, A. (1992) Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae. EMBO. J, 11, 3787-3796.
- Egli, M., Usman, N., Zhang, S. & Rich, A. (1992) Crystal structure of an Okazaki fragment at 2 Å resolution. Proc. Natl. Acad. Sci. USA. 89, 534-538.
- Zhang, S., Holmes, T., Lockshin, C. & Rich, A. (1993) Spontaneous assembly of a self- complementary oligopeptide to form a stable macroscopic membrane. Proc. Natl. Acad. Sci. USA 90, 3334-3338.
- Zhang, S., Lockshin, C., Cook, R. & Rich, A. (1994) Unusually stable beta-sheet formation of an ionic self-complementary oligopeptide. Biopolymers 34, 663-672.
- Zhang, S., Sanyal, I., Bulboaca, H., Rich, A. & Flint, D. (1994) The gene for biotin synthetase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli lacking biotin synthetase. Archives of Biochemistry & Biophysics 309, 29-35.
- Xing, Y., Zhang, S., Olesen, J., Rich, A & Guarente, L. (1994) Subunit interaction in the CCAAT- binding heteromeric complex is mediated by a very short a-helix in HAP2. Proc. Natl. Acad. Sci. USA 91, 3009-3013.
- Zhang, S. & Egli, M. (1994) A hypothesis: Reciprocal information transfer between oligoribonucleotides and oligopeptides in prebiotic molecular evolution. Origins of Life & Evolution of the Biosphere 24, 495-505.
- Zhang, S. & Egli, M. (1995) A proposed complementary pairing mode between single-stranded nucleic acids and beta-stranded peptides: A possible pathway for generating complex biological molecules. Complexity 1, 49-56.
- Zhang, S., Holmes, T., DiPersio, M., Hynes, R.O., Su, X. & Rich, A. (1995) Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials 16, 1385-1393.
- Zhang, S. & Rich, A. (1997) Direct conversion of an oligopeptide from a beta-sheet to an alpha- helix: A Model for amyloid formation. Proc. Natl. Acad. Sci. USA 94, 23-28.
- León, EJ, Verma, N., Zhang, S., Lauffenburger, D. & Kamm, R. (1998) Mechanical properties of a self-assembling oligopeptide matrix. J. Biomaterials Science: Polymer Edition 9, 297-312.
- Zhang, S., Yan, L., Altman, M., Lässle, M., Nugent, H., Frankel, F., Lauffenburger, D., Whitesides, G. & Rich, A. (1999) Biological surface engineering: A simple system for cell pattern formation. Biomaterials 20, 1213-1220.
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- Karagöl, A., Karagöl, T. & Zhang, S. (2025) Co-evolution of alpha-helical transmembrane protein residues: large-scale variant profiling and complete mutational landscape of 2,277 known PDB entries representing 504 unique human protein sequences. J. Mol. Evolution.93, 4. PMID: 40993375
- Sajeev-Sheeja A. Karagöl, A., Karagöl, T., & Zhang S. (2025) Molecular dynamics simulations and structural bioinformatics of bacterial integral alpha-helical membrane enzymes and their AlphaFold2-predicted water-soluble QTY variants. Molecular Simulation 15, 1029-0435.
- Rotteveel A, Lee WY, Kountouri Z, Stefanou N, Kivell H, Gluck C, Zhang S, Mershin A. Towards robust medical machine olfaction: Debiasing GC-MS data enhances prostate cancer diagnosis from urine volatiles. PLoS One. 2025, 20(5):e0314742. PMID: 40445905.
- Sajeev-Sheeja A. Karagöl, A., Karagöl, T., & Zhang S. (2025) Molecular dynamics simulations and structural bioinformatics of bacterial integral alpha-helical membrane enzymes and their AlphaFold2-predicted water-soluble QTY analogues. Molecular Simulation 15, 1029-0435.
- Karagöl, A., Karagöl, T. & Zhang, S. (2026) Integrative structural bioinformatics and molecular dynamics analyses of synaptic vesicle proteins and their water-soluble QTY-analogs reveal membrane constraints and evolutionary coupling of T<=>V. J. Molecular Evolution (Accepted).
- Karagöl, A., Karagöl, T. & Zhang, S. (2026) Multi-level comparative genomic analysis reveals evolutionary influence of truncated isoforms in glutamate transporter genes. J. Mol. Evolution (Revision under review).
- Hu, T., Chen, R., Chen, E. & Zhang, S. (2026) Structural bioinformatic studies of eight integral transmembrane NADPH oxidases and their AlphaFold 3 predicted water-soluble QTY analogs. PLoS ONE (Under revision).
- Zhang, Sophia, Chen, Edward, Zhang, S. (2026) Structure bioinformatics of five human rhomboid integral transmembrane proteases and their AlphaFold3 predicted water-soluble QTY analogs. (Under review).
Proceedings
- Zhang, S. (1996) Design and exploitation of self-assembling ionic complementary peptide systems: A model for peptide biomaterial engineering. Perspective in Protein Engineering 1996 (CDROM Edition) Geisow, M. Ed. Biodigm Ltd. UK, ISBN0-9529015-0-1.
- Zhang, S., Altman, M., Chan, R., Lee, P. & Ma, R. (1998) Self-assembling peptides in biology, materials science and engineering. Peptide Science: Present and Future. (Ed. Shimonishi, Y.) Kluwer Publishers, Amsterdam pp.761-768.
- Zhang, S. & Altman, M. (2001) Self-assembling peptide systems in biology, engineering and medicine. pp. 343-360. Crete Meeting Proceedings: Self-assembling peptide systems in biology, engineering and medicine (Ed. Aggeli, A., Boden, N. & Zhang, S.) Kluwer Academic Publishers, Dordrent, The Netherlands.
- Zhang, S. (2017) Discovery and design of self-assembling peptides. Interface Focus 7, 20170028. Other Publications:
Book Chapters
- Zhang, S. (2001) Molecular self-assembly. pp.5822-5829. Encyclopedia of Materials: Science & Technology, 1st Edition. Elsevier Science.
- Zhang, S., Altman, M., & Rich, A. (2001) Structural plasticity of peptides and proteins. pp.63-72. Diseases of Conformation – A Compendium Edited by Solomon, B., Taraboulos, A., & Katzir, E. Bialik Institute, N. Ben-Zvi Printing Enterprises, Ltd. Jerusalem, Israel.
- Santoso, S. & Zhang, S. (2004) Self-assembled nanomaterials. Vol 9, pp.459-471. Encyclopedia of Nanoscience and Nanotechnology. Edited by H. S. Nalwa, ISBN: 1-58883-001-2 (vols. 1-10).
- Kisiday, J. Zhang, S., Cosman, C., Sanz, S. & Grodzinsky, AJ. (2004) Self-assembling peptide hydrogel <a href="">scaffolds for cartilage tissue engineering. pp.349-353. In Tissue Engineering in Musculoskeletal Clinical Practice. (Ed. Sandell, L.J. & Grodzinsky, AJ.) American Academy of Orthopaedic Surgeons, Rosemount, IL, USA. .
- Zhang, S., Zhao, X., & Spirio, L. (2005) PuraMatrix: Self-assembling peptide nanofiber scaffolds In Scaffolding in Tissue Engineering. (Ed. Ma & Elisseeff) CRC Press, Boca Raton, FL pp.217-238.
- Zhang, S. Yokoi, H. & Zhao, X (2005) Molecular Design of Biological and Nano-Materials. pp.229-
- Biomimetics: Mimicking and Inspiration of Biology. Ed. Yoseph Bar-Cohen, CRC Press.
- Zhang, S. & Zhao, X. (2006) Designed Self-assembling Peptide Nanobiomaterials. pp.39-54. In Therapeutic Micro/Nano Technology: BioMEMS and Biomedical Nanotechnology (Ed. Desai & Bhatia) Springer, MA, USA.
- Zhang, S. (2007) Plausible lipid-like peptides in prebiotic molecular self-assembly in water. pp.440-
- In Fitness of the Cosmos for Life: Biochemistry and Fine-tuning, Cambridge University Press, Cambridge, UK.
- Horii, A., Wang, X & Zhang, S. (2008) Designer self-assembling peptide scaffolds for tissue engineering and regenerative medicine. pp.283-292. In Nanotechnology & Tissue Engineering: The Scaffold. (Ed. Nair, L.S.). Taylor & Francis Publishing, New York.
- Hosseinkhani, H., Hosseinkhani, M., Subramani, K. & Zhang, S. (2008) Self-assembly of nanomaterials for engineering cell microenvironment. pp. 275-290. Micro and Nanoenginernig of the cellular microenvironment: Applications and Technologies (Ed. Borenstein, J., Khademhosseini, A., Takayama, S. & Toner, M. Artech House Publishing, Boston, USA.
- Gelain, F., Wang, X., Horii, A., Koutsopoulos, S. & Zhang, S. (2010) Designer self-assembling peptides scaffolds for 3D tissue cell cultures. Method in 3D Culture, Chapter 4, pp. 59-81. Artech House. Boston, London.
- Zhang, S., Gelain, F. Yokoi, S., & Horii, A. (2011) Designer self-assembling peptide nanofiber scaffolds. Chapter 6, pp.123-147. Nanotechnology for Biology and Medicine: At the Building Block Level, (Ed. Silva, G.A. & Purpura, V.) Springer,
- Luo, Z. & Zhang, S. (2013) Structural properties and applications of self-assembling peptides. Chapter 20, pp.439-454. In Amyloid Fibrils and Prefibrillar Aggregates: Molecular and Biological Properties, (Editor: Otzen, D.E.) Wiley-VCH, Weinheim, Germany DOI:10.1002/9783527654185.ch20.
- Corin, K., Wang, X.Q. & Zhang, S. (2014) Production of olfactory receptors using commercial E.coli cell-free systems. Chapter 7, pp.115-126. Editor Tai Hyun Park in Bioelectronic Nose: Integration of Biotechnology and Nanotechnology, Springer Publishers.
Reviews
- Zhang, S. & Altman, M. (1999) Peptide self-assembly in functional polymer science and engineering. Reactive and Functional Polymers 41, 91-102.
- Zhang, S. (1999) Basic research in China, Science 283, 1850-1851.
- Aggeli, A., Boden, N. & Zhang, S. (1999) Two Sides of the Coin: Self-Assembling Peptide Systems in Biology, Medicine and Engineering. Molecular Medicine Today, 5, 512-513.
- Schwartz, J. & Zhang, S. (2000) Peptide-mediate cellular delivery. Current Opinion in Molecular Therapeutics 2, 162-167.
- Zhang, S. (2002) Emerging biological materials through molecular self-assembly Biotechnology Advances 20, 321-339.
- Santoso, S., Vauthey, S. & Zhang, S. (2002) Structures, functions, and applications of amphiphilic peptides. Current Opinion in Colloid & Interface Science 7, 262-266.
- Zhang, S. Marini, D. & Hwang, W., Santoso, S. (2002) Design nano biological materials through self-assembly of peptide & proteins. Current opinion in Chemical Biology 6, 865-871.
- Zhang, S. & Janciauskiene, S. (2002) Multi-functional capability of proteins: alpha1- antichymotrypsin and the correlation with Alzheimer's disease. J. Alzheimer’s Disease 4, 115-122.
- Zhang, S. (2003) A questioning mind. Nature 421, 581.
- Zhang, S. (2003) More Cinderella than ugly sister. Nature Review Genetics, 4, 243.
- Zhang, S. (2003) More Cinderella than ugly sister. Nature Review Mol. & Cell Biol, 4, 260.
- Zhang, S. (2003) Building from bottom-up. Materials Today 6, 20-27.
- Rich, A. & Zhang, S. (2003) Left-handed Z-DNA: the long road to biological function. Nature Review Genetics 4, 566-572.
- Zhang, S. (2003) Fabrication of novel materials through molecular self-assembly. Nature Biotechnology 21, 1171-1178.
- Zhang, S. & Semino, C. (2003) Design peptide scaffold for regenerative medicine. Adv Exp Med Biol. 534, 147-163.
- Zhang, S. (2004) Beyond the Petri Dish. Nature Biotechnology 22, 151-152.
- Zhang, S. (2004) Wet or let die. Nature Materials 3, 7-8.
- Zhang, S. Rich, A., Sussman, J. & Fersht, A. (2004) Carl-Ivar Brändén (1934-2004) Nature Structural & Molecular Biology 11, 491-493.
- Zhang, S. & Zhao, X. (2004) Design molecular biological materials peptide motifs. Journal of Material Chemistry 14, 2082-2086.
- Zhao, X & Zhang, S. (2004) Building from bottom up: Fabrication of molecular materials using peptide construction motifs. Trends in Biotechnology 22, 470-476.
- Zhang, S. (2005) Introduction. Seminars in Cancer Biology (Guest Editor) 15, 327-328.
- Zhang, S., Gelain, F. & Zhao, X. (2005) Designer self-assembling peptide nanofiber scaffolds for 3- D tissue cell cultures. Seminars in Cancer Biology 15, 413-420.
- Zhang, S. (2005) Designing novel materials and molecular machines. The Promise of Biotechnology -- Economic Perspective US State Department e-Journal, October issue, pp. 22-26.
- Mershin, A., Cook, B., Kaiser, L. & Zhang, S. (2005) A classic assembly. Nature Biotechnology, 23, 1379-1380.
- Zhao, X. & Zhang, S. (2006) Self-assembling nanopeptides become a new type of biomaterial. Adv. Polym Sci. 203, 145-170.
- Ellis-Behnke, R. So, K-F. & Zhang, S. (2006) Molecular repair of the brain using self-assembling peptides. Chemistry Today 24, 42-45.
- Zhang, S. Mershin, A. & Unsworth, L. (2006) Boston must take the lead in energy R&D. Nature Network Boston
- Zhao, X. & Zhang, S. (2006) Molecular designer self-assembling peptides. Chemical Society Reviews, 35, 1105-1110.
- Zhang, S. (2006) Another brick in the wall. News & Views, Nature Nanotechnology 1, 169-170.
- Zhao, X. & Zhang, S. (2007) Designer self-assembling peptide materials. Macromolecular Bioscience 7, 13-22.
- Gelain, F., Horii, A. & Zhang, S. (2007) Designer self-assembling peptides for 3D tissue cell cultures and regenerative medicine. Macromolecular Bioscience 7, 544-551.
- Zhang, S. (2007) Designer self-assembling peptide nanofiber scaffolds for study of 3-D cell biology and beyond. Advances in Cancer Research 99, 335-362.
- Zhang, S. (2007) Cambridge vs. Cambridge: a personal comparison. Nature Network.
- Zhang, S. (2007) Reactions The Sceptical Chymist, Nature Chemistry.
- Chen, L.B, Hartman, S., Zetter, B. & Zhang, S. (2007) John M Buchanan (1917-2007) Protein Science 16, 2578–2579.
- Yang, Y. Khoe, U., Wang, X., Horii, A., Yokoi, H., & Zhang, S., (2009) Designer self-assembling peptides nanomaterials. Nano Today 4, 193-210.
- Hauser, C.A.E. & Zhang, S. (2010) Designer self-assembling peptide biological materials. Chemical Society Reviews. 39, 2780-2790.
- Hauser, C.A.E. & Zhang, S. (2010) Designer self-assembling peptide materials for diverse applications. Macromolecular Symposia 295, 30-48.
- Hauser, C.A.E. & Zhang, S. (2010) Peptides as biological semiconductors. Nature 468, 516-517.
- Zhao, X, F Pan, H Xu, M Yaseen, H Shan, CAE Hauser, S Zhang, & JR Lu (2010) Molecular self- assembly and applications of designer peptide amphiphiles. in Peptide and Protein-based Materials: Present and Future. (Ed. D. Woolfson & R. Ulijn). Chemical Society Reviews. 39, 3480-3498.
- Koutsopoulos, S., Kaiser, L., Eriksson, H.M. & S. Zhang (2012) Designer peptide surfactants stabilize diverse functional membrane proteins. Chemical Society Reviews. 41, 1721-1728.
- Loo, E., Zhang, S. & Hauser, C.A.E. (2012) From short peptides to nanofibers to macromolecular assemblies in biomedicine. Biotechnology Advances 30, 593-603.
- Lakshmanan, A., Zhang, S. & Hauser, C.A.E. (2012) Short self-assembling peptides as building blocks for modern nanodevices. Trends in Biotechnology 30, 155-165.
- Wu, E., Zhang, S. & Hauser, C.A.E. (2012) Self-assembling peptides as cell-interactive scaffolds. Advanced Function Materials 22, 456-468.
- Luo, Z. & Zhang, S. (2012) Designer nanomaterials using chiral self-assembling peptide systems and their emerging benefit for society. Chemical Society Reviews 41, 4736-4754.
- Zhang, S. (2012) Self-assembling materials peptide. Amino Acids, Peptides and Proteins 37, 40-65.
- Zhang, S. (2012) Lipid-like self-assembling peptides. Accounts of Chemical Research 45, 2142-2150.
- Corin, K., Cook, B. & Zhang, S. (2013) A robust, rapid, and simple method of producing olfactory receptors using commercial E. Coli cell-free systems. Methods in Molecular Biology 1003, 101-108.
- Zhang, S. & Wittig, B. (2015) Alexander Rich (1924-2015). Nature Biotechnology 33, 593-598.
- Zhang, S. (2018) Discovery of the first self-assembling peptide and study of peptide dynamic behaviors and G protein-coupled receptors using Aviv CD. Biopolymers 109 DOI: 10.1002/bip.23235.
- Zhang, S. (2018) Jack Aviv: An incredible, generous and humble human being. Biopolymers 109 DOI: 10.1002/bip.23228.
- Zhang, S. (2020) Self-assembling peptides: from a discovery in a yeast protein to diverse uses and beyond. Protein Science 29 (11) 2281-2303. PMID: 32939884
- Gelain F., Luo, Z., & Zhang, S. (2020) Self-assembling peptide EAK16 and RADA16 nanofiber hydrogel scaffolds. Chemical Reviews 120 (24) 13434–13460.
- Gelain F., Luo, Z., Rioult, M. & Zhang, S. (2021) Self-assembling peptide scaffolds in the clinic. NPJ Regenerative Medicine 6, article 9. PMID: 33597509
- Egli, M. & Zhang, S. (2021) Remembering a giant of chemical crystallography. Nature 598(7879),
- PMID: 34611357
- Egli, M., & Zhang, S. (2022) First prediction of sequence-specific recognition of double-helix nucleic acids by proteins. Nat Rev Mol Cell Biol. 23, 166. PMID: 35022569
- Egli, M., & Zhang, S. (2022) How the alpha-helix got its name. Nat Rev Mol Cell Biol. 23, 165. PMID: 35075297
- Egli, M., & Zhang, S. (2022) Ned Seeman and the prediction of amino acid-base pair motifs mediating sequence-specific recognition of nucleic acid duplexes by proteins. Biophysical Journal. S0006-3495(22)00476-3. PMID: 35711143
- Zhang, S. & Egli, M. (2022) Hiding in plain sight: three chemically distinct α-helix types. Quarterly Review of Biophysics (QRB) 55, e7. PMID: 35722863
- Qing, R., Hao, S.L., Smorodina, E, Zalevsky, A., Jin, D. & Zhang, S. (2022) Protein design: from the aspect of water solubility and stability. Chemical Reviews 122, 14085-14179. PMID:35921495
- Zhang, S. (2022) A tribute for George and Eva Klein. Dear Eva, Dear George, 180 years and beyond. The George and Eva Foundation. Stockholm. pp.142-147. ISBN 978-91-639-7389-5 Anahit AB.
- Zhang, S. (2022) Life has its ups and downs, always ask questions. Molecular Frontiers Journal, Vol. 6, No. 01n02, 24-45.
- Zhang, S. (2023) Good mentors are critical for young people’s career development. Molecular Frontiers Journal 7, 55-59,
- Egli, M. & Zhang, S. (2023) Making sense of helices: right and wrong models in science and art. Molecular Frontiers Journal
- Zhang, S. & Egli, M. (2024) ALEXANDER RICH, National Academy of Sciences Biographic Memoir. National Academy of Sciences Press.
- Zhang S. (2025) Protein Design: Entering the age of designer protein materials. News & Views, Nature Materials 24(10) 1515-1517.
Lectures
- (Invited lectures at some of the same institutions are multiple times)
- Swiss Institute of Technology (ETH) Zürich, Switzerland, 1993, 1995, 2000,2019
- Karolinska Institute Stockholm, Sweden, 1999, 2003, 2004,
- 2005, 2006, 2019
- University of Uppsala Uppsala, Sweden, 2004, 2008
- University of Oslo Oslo, Norway, 1995, 2003
- Norwegian University of Science & Technology Trondheim, Norway, 2003
- University of Padova Padova, Italy 2001
- University of Camerino Camerino, Italy, 2002, 2003
- Freie University Berlin, Germany, 1993, 1995, 1998,2007
- Germany, Hans-Knoll Institute Jena, Germany, 1995
- Technical University of Munich Munich, Germany, 2006
- Polish Academy of Sciences Warsaw, Poland, 1995, 2006
- University of Cambridge, Department of Biochemistry Cambridge, UK, 2006
- University of Cambridge, Department of Chemistry Cambridge, UK, 2007
- MRC-Laboratory of Molecular Biology Cambridge, UK, 2007
- MRC-Protein Engineering Center Cambridge, UK, 2007
- Roslin Institute Roslin, Scotland, UK, 2003
- University of Edinburgh Edinburgh, Scotland, UK, 2003, 2007
- Center for Self-organization Systems, University of Leeds Leeds, UK 1997, 2003
- University of Sheffield, Department of Biochemistry Sheffield, UK, 2001
- University of York York UK, 2000
- University of Essex, Department of Biochemistry Essex, UK 2007
- University of Manchester, Department of Materials Manchester UK 2007
- Department of Biochemistry, CNRS Gif-sur-Yvett, France 1996
- Service de Chimie Moléculaire, C.E.A. Saclay, France, 2004
- UNITE INSERM Paris, France, 1996
- Ludwig Boltzmann Institute for Experimental & Clinical
- Traumatology
- Vienna, Austria 2006, 2008
- Departments Biological Chem. The Weizmann Institute Rehovot, Israel, 1998
- Structural Biology, The Weizmann Institute Rehovot, Israel, 1995, 2008
- Hebrew University of Jerusalem Jerusalem, Israel 1995
- Ben-Gurion University of the Negev Beer Sheva, Israel, 1997, 1998, 2000,2005, 2008
- Protein Research Institute, Osaka University Osaka Japan, 1997
- Tokyo Institute of Technology Tokyo, Japan, 2000
- Department of Chemical Engineering, University of Tokyo Tokyo, Japan, 2001
- Electrical Engineering, University of Tokyo Tokyo, Japan, 2005
- Department of Materials, University of Kyoto Kyoto, Japan, 2002
- Japan International Center of Medical Science Tokyo, 1998, 2003
- Department of Biology, Waseda University Tokyo, Japan, 1997, 2000
- Department of Materials, Nagoya Institute of Technology Nagoya Japan, 2001
- Department of Materials, Tohoku University Sendai, Japan, 2006, 2008
- Osaka National Research Institute Ikeda, Japan, 1997
- National University of Singapore Singapore, 2000
- Qinghua University Beijing, China, 1998-2004
- Beijing University Beijing China, 2004
- Chinese Academy of Medical Sciences Beijing, China, 1991, 1996, 1998,2002, 2004
- Sichuan University Chengdu, China, 1986, 1991, 1996-2006
- Hong Kong University of Science & Technology Hong Kong 2002, 2007
- Knight Fellows Lecture Series MIT, MA, 2004, 2005, 2006
- MIT-various Departments, Centers, Labs, Groups Cambridge, MA, 1989-2020
- Harvard University Cambridge MA 1994
- Harvard Medical School Boston MA 1997
- Tufts University Medford, MA 2005
- Tufts University Medical School Boston, MA, 1996, 2002, 2004
- Boston University Boston, MA, 1996, 2003
- California Institute of Technology Pasadena CA, 2001
- Stanford University Stanford, CA 2002
- Scripps Research Institute La Jolla CA, 1999
- University of California at San Francisco San Francisco CA, 1996, 2002, 2018
- University of California at Santa Barbara Santa Barbara, CA, 1991, 1996, 2001
- University of California at Davis Davis, CA, 1996
- University of Washington Seattle, WA, 1999
- University of Toronto Toronto, Canada, 2000
- University of Waterloo Waterloo, Canada, 2000
- McMaster University Canada 2006
- Vanderbilt University Nashville, Tenn. 2005
- Lehigh University Pennsylvania 2006
- Naval Research Laboratories Washington, D.C. 1999, 2003
- Defense Advanced Research Project Agency Arlington, VA, 2000-2003, 2011
- Intel Corporation Santa Clara, CA, 2001, 2003
- Intel Corp. Research Center Hillsboro, OR, 2004
- Novartis Institute for Biomedical Research Cambridge, MA. USA, 2004
- Johnson & Johnson New Jersey, 1995
- Du Pont, & Co. Wilmington, DE, 2001, 2003
- Hercules, Inc. Wilmington, DE, 1995
- Institute of Human Virology Baltimore, MD, 2001, 2004
- BioWhittaker Walkersville, MD, 2004
- Biosurface Technology Cambridge, MA, 1995
- Convatec Chester, UK, 1999
- Convatec, Skillman New Jersey, USA, 1996
- Beckton-Dickinson Bedford, MA, 1995, 1998
- Acorda Therapeutics New York, 1996-2001
- EngeneOS Waltham, MA, 2001
- Mitsubishi Chemical Corp. Yokohama, Japan, 1996-2005
- Takeda Pharmaceuticals Osaka, Japan, 1999
- Menicon, Co. LTD Nagoya, Japan, 1999-2007
- Teijin, Ltd. Hino Tokyo, Japan, 2003, March 2010
- Mitsui Chemical Corp. Tokyo, Japan, 2007
- Dai Nippon Printing Tokyo, Japan, 2007
- Perspective in Protein Engineering Montpelier, France, April 1996
- Perspective in Protein Engineering Norwich, UK, June 1997
- Condensed Soft Matter Symposium Tel Aviv, Israel, April 1997
- Peptide Engineering Symposium Ikeda, Japan Oct. 1997
- Peptide Science & Technology Kyoto, Japan Oct. 1997
- Active & Functional Biopolymers Symposium Jerusalem, Israel, July 1998
- The Era of Biotechnology Beer Sheva, Israel Oct. 2000
- Materials Research Society Fall Meeting Boston, MA Dec. 2001
- Stem Cell & Progenitors: Biology and Applications Cold Spring Harbor, Sept. NY 2001
- Fourth World Congress on Brian Injury Torino, Italy, May 2001
- Engineering Tissue Growth International Conference Pittsburgh, PA, May 2001
- The Frontier of Biomaterials, University of Delaware Wilmington, DE, Oct. 2002
- Self-assembly: The Future Massa Marittima, Italy, May 2002
- American Chemical Society Symposium, Biotechnology
- Section
- Boston MA July 2002
- Third Conference on Regenerative Medicine Washington, D.C. November 2002
- Biology of Chirality Modena, Italy, April 2003
- Second International Conference on Biomaterials Cardiff, Wales, UK April 2003
- Royal Society of Chemistry: Frontier of Chemical Biology Manchester, UK, September 2003
- Glaucoma Foundation Think Tank Meeting Boston, Sept. 2003, 2004, 2005, 2007
- Materials Research Society Fall Meeting Boston, Dec. 2003
- Ophthalmology Annual Meeting New York, January 2004
- Materials Research Society Spring Meeting San Francisco, CA March 2004
- 3rd Congress of Japan Society of Regenerative Medicine Tokyo March 2004
- 43rd Polymer Biomaterials: Biomimetic & Bioanalogous
- Systems
- Prague, Czech July 2004, 2009
- 1st Nanobiotechnology Symposium Singapore, Sept. 2004
- 7th New Jersey Biomaterials Conference, Rutgers
- University
- New Jersey, Oct. 2004
- Glaucoma Foundation Think Tank Meeting New York, 2004, 2005 & 2007
- Observatoire des Micro & Nano Technologies – OMNT Paris, France, Dec. 2004
- Shell Corporation, Amsterdam, The Netherlands Dec. 2004 & January 2006
- American Chemical Society Spring Meeting San Diego March 2005
- American Chemical Society Summer Meeting Washington, D.C. August 2005
- Materials Research Society Spring Meeting San Francisco, March 2005
- The Schrödinger Society Lecture Vienna, Austria, April 2005
- 6th European Protein Society Barcelona, Spain, May 2005
- Protein Design Workshop Jerusalem, Israel, May 2005
- 4th Multidiscipinary workshop: Self-assembling peptides &
- proteins
- Crete, Greece, June 2005
- The Nobel Symposium: "Molecular oncology-from bench
- to bedside” Karolinska Institute
- Stockholm, Sweden, June 2005.
- International Symposium on Molecular Nanotechnology Nara, Japan, Nov. 2005
- European Synchrotron Radiation Facility Grenoble, France, January 2006
- Shell Oil Research Center, Amsterdam The Netherlands, January 2006
- Institute of Bioengineering & Nanotechnology Singapore, Feb. 2006
- University of Indonesia Jakarta, Indonesia. Feb. 2006
- 5th Annual Japan Society of Regenerative Medicine Okayama, Japan, March 2006
- 29th Annual Japan Society for Future of Medicine Tokyo, Japan, March 2006
- Nanotech 2006 Boston, MA, USA, May 2006
- The Nobel Workshop “Chemical Origins of Life” Stockholm, Sweden, June 2006
- “What Is Life?” Lecture Series, Karolinska Institute Stockholm, Sweden, June 2006
- 1st International Conference of Nanobiomedical
- Technology & Structural Biology
- Chengdu, China, 6/2006
- 29th European Peptide Symposium Gdansk, Poland, Sept. 2006
- University of Cambridge, Department of Materials Science
- & Metallurgy
- Cambridge, UK, Oct. 2006
- University of Cambridge, Department of Biochemistry Cambridge, UK, Oct. 2006
- Ludwig Boltzmann Inst. Experi. & Clinical Traumatology Vienna, Austria, Nov. 2006
- MRC-Laboratory of Molecular Biology Cambridge, UK, Jan. 2007
- University of Cambridge, Department of Chemistry Cambridge, UK, Feb. 2007
- Nobel Workshop: “Molecular Frontiers” Stockholm, Sweden, February 2007
- Northern European Nanotechnology Conference Helsinki, Finland, March 2007
- Department of Virology, University of Helsinki Helsinki, Finland, March 2007
- Biomedical Graduate School, University of Helsinki Helsinki, Finland, March 2007
- Drug Delivery Technology Center, University of Helsinki Helsinki, Finland, March 2007
- MIT Alumni Club-Florida Chapter Tampa, FL, April 2007
- 7th European Protein Society Stockholm-Uppsala, Sweden, May 2007
- High Content Analysis Conference Vienna, Austria, June 2007
- Depart Cell Biology & Biophysics, University of Athens Athens, Greece, July 2007
- Ipsen-Biomeasure, Inc. Milford, MA, Oct. 2007
- MRS-Fall Symposium, Boston, November 2007
- Department of Chemistry, EPFL, Lausanne, December 2007
- 2nd Molecular Frontiers Symposium Singapore, January 2008
- University of Indonesia Jakarta, January 2008 and August 2011
- MIT-Japan Symposium Tokyo, 1-2008
- The Katzir Workshop: The Unbearable Complexity of Life, Tel Aviv, Israel, 2-2008
- Surfaces & Interfaces in Soft Matter & Biology, Institute
- Laue-Langevin
- Grenoble, France, 5-2008
- Karolinska Institute Stockholm, Sweden, May 2008
- Uppsala University, Department of Pathology Uppsala, Sweden, May 2008
- Frontiers of Membrane Biology Mykonos, Greece, May 28-June 1, 2009
- 10th Cell-Biomaterials Interactions Porto, Portugal, June 22-26, 2009
- 73rd Prague Meeting on Macromolecular Science Prague, Czech Republic, 5-9 July 2009
- First Nano Today Conference, Singapore August 2-5, 2009
- 5th Benzon Symposium: Funct & Pathog protein aggregation, Copenhagen, 8/24-27, 2009
- 3rd Biomaterials Research & Development in South Africa September 20-22, 2009
- Molecular Foundry Distinguished Lecture, Lawrence 3-2-2010
- Berkeley National Laboratory
- European Materials Research Society Strasbourg, France, June 6-10, 2010
- 2nd Conference on Chemical & Molecular Bioengineering Singapore, 8-2010
- University of Århus Århus, Denmark, September 2010
- International Workshop on Synthetic Biology Copenhagen, Denmark, 8/25-27, 2010
- Workshop BOKU-Austrian Institute of Technology Vienna, September 12-15, 2010
- President’s Lecture Series, CSIR Pretoria, South Africa, 9-2010
- US State Department Sponsored Lect at Univ. of Mauritius Port Louis, Mauritius 9-2010
- Forschungszentrum Juelich Juelich, Germany 5-2011
- Givandan AG Dubendorf, Switzerland 6-2011
- China Biotechnology Vista Taicang, China 7-2011
- Nanjing University Nanjing, China 7-2011
- Bioengineering and Biotechnology Workshop China University of Petroleum, 7-2011
- Harvard and Stanford Club and @America Jakarta, Indonesia, 8-2011
- Austrian Institute of Technology Nanobiotechnology Vienna, Austria, 9-2011
- Genomic Symposium Rome, Italy, 10-2011
- Protein Engineering Symposium Boston, MA 4-2012
- Nanyang Technological University Singapore 5-2012
- China University of Petroleum Qingdao, China, 7-2012
- University of Catania Catania, Italy, 8-2012
- Gen9 Cambridge, MA, 12-2012
- Membrane Proteins: Functions, Structures and Diseases Taiwan, 5-2013
- Peptides & Proteins: Structure, Function & Biotechnology Le Mans, France, 7-2013
- Alex in Wonderland II, MIT Media Lab Cambridge, MA, 6-2014
- 10th Nanoscience & Nanotechnology of Conference Istanbul, Turkey, 6-2014
- MIT ILP Wuxi Symposium Wuxi, China, 5-2015
- MIT Sloan School Executive Education Cambridge, MA, 8-2105
- Technology Forum 2015 Alpbach, Tyrol, Austria
- MIT Sloan School-Boeing Education for China Cambridge, MA, 11-2015
- Tosoh Corporation Tokyo, Japan, 11-2015
- University of Lund Lund, Sweden, 6-2016
- Institute of Science & Technology Vienna, Austria, 6-2017
- Austrian WKO, MIT ILP Vienna, Austria, 6-2017
- MIT LIP Symposium Shanghai, China, 10-2017
- Weizmann Institute of Science Rehovot, Israel, 12-2017
- Tel Aviv University Tel Aviv, Israel, 12-2017
- Israel Arts and Science Academy Jerusalem, Israel, 12-2018
- Austrian WKO Symposium Vienna, Austria, 4-2018
- Sanofi-Paris, France Paris, France, 4-2018
- Louis Pasteur Institute Paris, France, 4-2018
- 3rd Proteins and Peptides Conference Geneva, Switzerland, 7-2018
- Proteins & Interfaces, University of Catania, Catania, Sicily, Italy, 9-2018
- Beijing Zhongguancun Biotechnology Center MIT ILP Beijing, China, 11-2018
- Shanghai Science and Technology Office special lecture Shanghai, China, 11-2018
- Molecular Frontiers Symposium, MIT Media Lab Cambridge, MA, 11-2018
- Russian Acad of Sci., Institute of Bioorganic Chemistry Moscow, Russia, 12-2018
- Russian Acad. of Sci., Institute of Protein Research Pushchino, Russia, 12-2018
- Boston Asian Biomedical Association Waltham, MA, 1-2019
- Baidu Internet Search Company, MIT ILP Beijing, China, 4-2019
- China High Speed Train Company Research, MIT ILP Liuzhou, China, 4-2019
- Wuhan University Alum Club, MIT Cambridge, MA, 4-2019
- Karolinska Institute, Sweden Stockholm, Sweden, 5-2019
- Lund University, Sweden Lund, Sweden, 5-2019
- ASST Niguarda Ca’Granda Hospital, Milan, Italy, 6-2019
- ETH-Swiss Institute of Technology Zürich, Switzerland, 6-2019
- Tongrentang Traditional Chinese Medicine, MIT ILP Beijing, China 10-2019
- Defond Electech Co. Ltd, Hong Kong, MIT ILP Hong Kong, 10-2019
- Midea Group, MIT ILP Songde, China, 1-2020
- World Stem Cell Summit Online 6-2021
- Protein Society Symposium Online 7-2021
- Chinese American Biotechnology Summit Online 10-2021
- 20th Erwin Schrödinger Colloquium, Austrian Academy of Sciences, Vienna, Austria 12-2021
- Austrian Chamber of Commerce (WKO) Vienna, Austria 12-2021
- Austrian Academy of Sciences Vienna, Austria 7-2022
- Hebrew University Jerusalem, Israel 1-2023
- Weizmann Institute of Science Rehovot, Israel 1-2023
- Tel Aviv University Tel Aviv, Israel 1-2023
- University of California at Los Angeles Los Angeles, California 2-2023
- University of California at Santa Barbara Santa Barbara, California 3-2023
- University of Cambridge, UK, Department of Biochemistry Cambridge, UK 4-2023
- MRC-Laboratory of Molecular Biology Cambridge, UK 4-2023
- 4th Proteins and Peptides: Structure, Function & Biotechnology Geneva, Switzerland 7-2023
- 3D Matrix Medical Technology Lyon, France 7-2023
- University of Florence Florence, Italy 9-2023
- University of Padova Padova, Italy 9-2023
- Arizona State University Tempe, Arizona 12-2023
- MIT Alumnus Club-Shanghai Zoom Online 3-2024
- Paris-Lodron University of Salzburg Salzburg, Austria, 4-2024
- Austrian Academy of Sciences Vienna, Austria 4-2024
- Cancer Center of Karolinska Institute Stockholm, Sweden, 4-2024
- George Klein Lecture, Karolinska Institute Stockholm, Sweden, 4-2024
- Lund University Lund, Sweden 4-2024
- University of California at Irvine Irvine, CA 11-2024
- Molecular Frontiers Symposium Hong Kong, 11-2024
- CAS Institute of Biochemistry and Cell Biology Shanghai, 11-2024
- Fudan University, Shanghai Academy of AI for Science Shanghai, 11-2024
- UltraDx Biotechnology (Shanghai) Co. Ltd. Shanghai, 11-2024
- CAS-Shenzhen Institute of Advanced Technology Shenzhen, 11-2024
- Catalysis and Reaction Engineering conference Newton, MA 2-2025
- McGovern Institute for Brian Research, MIT Cambridge, MA 4-2025
- 5th Proteins and Peptides: Structure, Function & Biotechnology Geneva, Switzerland 7-2025
- Frontiers of Tumor Biology: International symposium Stockholm, 9-2025
- to honour Eva and Georg Klein celebrating 200 years
- A symposium to honor Dr. Meir Wilchek, Weizmann Institute Rehovot, Israel, 10-2025
- HK Biotech 2026 Hong Kong, 9-2026
- Invited special participant or session chair
- Joint Nobel Symposia: Energy in Cosmos, Molecules & Life Stockholm, 18-22 June 2005
- 1st Molecular Frontiers Symposium: Nanotechnology Stockholm, Sweden, 2-3/2/2007
- 3rd Molecular Frontiers Symp.: Catalysis & Solar Energy Stockholm, 3-5 June 2008
- 4th Molecular Frontiers Symposium: Of Molecules & Mind Stockholm, 5-6 June 2009
- 5th Molecular Frontiers Symp.: Alternative Energy &
- Molecules
- Stockholm, 2-4 June 2010
- 6th Molecular Frontiers Symp.: The Chemical Origin of Life Stockholm, 23-25 May 2011
- 7th Molecular Frontiers Symposium: How Chemical Cycles
- Shape Our Planet
- Stockholm, 5-2012
- 8th Molecular Frontiers Symposium: The Extremes of Life Stockholm, 5-2013
- 9th Molecular Frontiers Symposium: The Brain:
- Achievements & Challenges
- Stockholm, 5-2014
- 10th Molecular Frontiers Symposium: Göteborg, Sweden 5-2015
- Future of Tumor Biology, Karolinska Institute, Stockholm, Sweden, June 16-18, 2015
- 11th Molecular Frontiers Symposium: Water Tokyo, November 7-8, 2016
- 12th Molecular Frontiers Symposium: Man-Tailored Biology Stockholm, Sweden, May 22-23, 2017
- 14th Molecular Frontiers Symposium: Planet Earth Stockholm, Sweden, May 9-10, 2019
- 15th Molecular Frontiers Symposium: UC Berkeley, California, March 3-4, 2023
- 16th Molecular Frontiers Symposium: Lund, Sweden, April 18-19, 2024
- 17th Molecular Frontiers Symposium: Frontiers of Scientific Knowledge, Hong Kong, November 15-17,
- 2024
- 18th Molecular Frontiers Symposium: DNA beyond the secret of Life, New York, November 15-16, 2025
MIT Press
- MIT Institutional Research Highlights (Office of the Provost, 1993 & 2004)
- Peptide plus salt makes membrane
- A new material for tissue engineering?
- Self-assembling peptides
- Researchers zero in on cell malfunction causing Alzheimer's
- New biomaterial is able to support living nerve cells
- Peptide/protein self-assembly applications touted at conference
- New nanomaterial could slide into future soap
- Technique could improve cartilage repair
- Cartilage technique holds promise for injuries, arthritis
- MIT senior lands story in journal, trip to D.C.
- A serendipitous discovery
- Special bond links scientists and their peptides: New scientific field poised for widespread applications
- Biology: the ultimate robotics
- Green, leafy spinach may soon power more than Popeye's biceps
- Three at MIT conceive cell-shaped building
- MIT researchers restore vision in rodents blinded by brain damage
- MIT creates 3D scaffold for growing stem cells
- Austrian honor for Zhang
- Leading MIT scientists join effort to mentor youth
- Awards and Honors: Guggenheim Fellowship
- MIT material stops bleeding in seconds: MIT unveils new treatment for wounds
- NMR advance relies on microscopic detector
- Sniffing out success
- Preventing forest fires with tree power: Sensor system runs on electricity generated by trees
- New gel offers controlled drug delivery: Self-assembling hydrogel could help treat cancer and diabetes, among other diseases
- Zhang inducted into Austrian Academy of Sciences
- Teaching algae to make fuel: New process could lead to production of hydrogen using bioengineered microorganisms.
- Harnessing nature’s solar cells: Photovoltaic panels made from plant material could become a cheap, easy alternative to traditional solar cells.
- Growing a business, from the lab: MIT researcher Shuguang Zhang’s nanofiber-scaffold technology became the foundation for a biotech company.
- Scientists alter membrane proteins to make them easier to study
- Following a code for swapping amino acids makes membrane proteins water soluble
- Making chimeric versions of chemokine receptors
- Proteins may halt the severe cytokine storms seen in Covid-19 patients
- Truncated immune system receptors may regulate cellular activity
- New research transforms glucose transporter proteins to water-soluble form.
- New sensor mimics cell membrane functions.
- Protein study could help researchers develop new antibiotics.